Abstract: In this paper, a modified Smith predictor control scheme is proposed for periodic disturbance rejection in both stable and unstable processes with time delay. Without affecting the superior setpoint response of Smith predictor control, the regulation performance under periodic disturbance can be enhanced significantly by the proposed design. Meanwhile, the asymptotical rejection for non-periodic disturbance will also be improved. Internal stability is investigated for a closed-loop control system. The effectiveness of the proposed scheme will be demonstrated by simulations as well as a test on an experimental thermal system.